Ascorbic acid accelerates Wallerian degeneration after peripheral nerve injury

L Li, Y Xu, X Wang, J Liu, X Hu, D Tan… - Neural Regeneration …, 2021 - journals.lww.com
Schwann cells and macrophages are the main cells involved … Furthermore, ascorbic acid
inhibited myelin-associated … , promoting the dedifferentiation of Schwann cells, and enhancing …

Autophagic myelin destruction by Schwann cells during Wallerian degeneration and segmental demyelination

SY Jang, YK Shin, SY Park, JY Park, HJ Lee, YH Yoo… - Glia, 2016 - Wiley Online Library
… for Schwann cell dedifferentiation and remyelination. A: SC … in vivo and even ex vivo,
and that the progression of P-type to D-type fibers was significantly delayed in lysosome-inhibited

Inhibition of neuronal nitric oxide synthase by ethyl pyruvate in schwann cells protects against peripheral nerve degeneration

HJ Chung, M Kim, J Jung, NY Jeong - Neurochemical Research, 2019 - Springer
… during Wallerian degeneration, because the ex vivo modelSchwann cell dynamics (eg,
demyelination, dedifferentiation, proliferation, and transcriptional regulation) during Wallerian

Role of microtubule dynamics in Wallerian degeneration and nerve regeneration after peripheral nerve injury

J Liu, L Li, Y Zou, L Fu, X Ma, H Zhang… - Neural regeneration …, 2022 - journals.lww.com
… explants, an in vitro model of Wallerian degeneration, with the … degeneration and Schwann
cell dedifferentiation, whereas nocodazole-induced microtubule destabilization inhibited

The natural plant flavonoid apigenin is a strong antioxidant that effectively delays peripheral neurodegenerative processes

M Kim, J Jung, NY Jeong, HJ Chung - Anatomical Science International, 2019 - Springer
inhibits Schwann cell trans-dedifferentiation during ex vivo … could be ignored during ex vivo
Wallerian degeneration. Taken … inhibited Schwann cell proliferation during peripheral nerve …

Heme oxygenase 1 in Schwann cells regulates peripheral nerve degeneration against oxidative stress

M Kim, H Kim, D Kim, D Kim, Y Huh, C Park… - ASN …, 2019 - journals.sagepub.com
… that demyelinating Schwann cells during Wallerian degeneration … regulates Schwann cell
proliferation ex vivo. (a) Confocal … such Schwann cells are known as dedifferentiated or repair …

Macrophages influence Schwann cell myelin autophagy after nerve injury and in a model of Charcot‐Marie‐Tooth disease

EM Weiß, M Geldermann, R Martini… - Journal of the …, 2023 - Wiley Online Library
… that Wallerian degeneration (WD) might be helpful as a model… and autophagic pathways
in the ex vivo model of WD, we … ” could plausibly foster SC dedifferentiation and subsequent …

The histone deacetylase class I, II inhibitor trichostatin A delays peripheral neurodegeneration

M Kim, C Park, J Jung, SG Yeo - Journal of Molecular Histology, 2019 - Springer
… suppresses Schwann cell trans-dedifferentiation during ex vivo … Phosphorylated
extracellular-signal-regulated kinase (pERK)… Schwann cell proliferation during ex vivo peripheral …

Ex vivo assay of electrical stimulation to rat sciatic nerves: cell behaviors and growth factor expression

Z Du, O Bondarenko, D Wang… - Journal of Cellular …, 2016 - Wiley Online Library
… accelerate Wallerian degeneration and help Schwann cells … buffer with protease and
phosphatase inhibitor cocktails and then … during the dedifferentiation of Schwann cells upon …

Protein kinase cα promotes proliferation and migration of Schwann cells by activating ERK signaling pathway

J Li, Z Zhang, J Wang, S Du, D Yao, R Cao, S Cui - Neuroscience, 2020 - Elsevier
Wallerian degeneration (WD) and axon regeneration … Knockdown of PKCα inhibits SC
proliferation and migration in vitrodedifferentiation or myelinophagy of SCs, but not be included in …